PeptideMed PlusClinical evidence
Peptides/KPV
🛡️ Immunity & Anti-inflammatory

KPV (α-MSH(11-13) · Lys-Pro-Val)

Anti-inflammatory tripeptide derived from alpha-MSH

Also known as:
α-MSH(11-13)Lys-Pro-ValLisil-Prolil-ValinaKPV tripeptide

What is KPV

KPV is the C-terminal tripeptide (Lys-Pro-Val) of the hormone alpha-MSH, with potent local anti-inflammatory action without the pigmentary effect of the full peptide. It acts by reducing NF-κB signaling and the production of pro-inflammatory cytokines, with described affinity for the PepT1 transporter in the intestinal epithelium. Preclinical studies in colitis models (Dalmasso et al., Gastroenterology 2008) demonstrated reduced mucosal inflammation through oral and topical administration.

Administration Protocol

PRO
1
Dose (research)
200-500 mcg per day
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Community reviews

4.7(6)
Diego S.

Uso há algumas semanas e os resultados começaram a aparecer. Protocolo bem explicado aqui no site, ajudou muito.

07 de abr. de 2026
Gustavo T.

Boa resposta no geral. Demorou um pouco mais do que eu esperava, mas valeu a pena seguir o protocolo certinho.

01 de abr. de 2026
Bruno G.

Diferença perceptível na recuperação e disposição. A linha do tempo do site bate bastante com a minha experiência.

26 de mar. de 2026
Mariana A.

Funciona, mas exige consistência. As informações de armazenamento e reconstituição foram essenciais pra mim.

31 de dez. de 2025
Juliana O.

Resultado dentro do esperado. Importante respeitar a titulação descrita aqui pra evitar desconforto.

25 de dez. de 2025
Aline B.

Qualidade do conteúdo é nível clínico mesmo. Acompanho os protocolos e tenho indicado pra amigos.

19 de dez. de 2025

Side effects

  • •Favorable safety profile in preclinical studies; human data are limited. Irritation may occur at the site of topical or subcutaneous application.

Contraindications

  • •Pregnancy and lactation. Use not established in humans; should be avoided outside a research context. Hypersensitivity to the compound.

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Where to buy

KPV from Royal Peptides — lab-tested purity and worldwide shipping.

View on Royal Peptides

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Quick Facts

ClassificationTripeptide (fragment of alpha-MSH)
Half-lifeShort (minutes to a few hours)
CategoryImmunity & Anti-inflammatory
Evidence LevelPré-clínico (forte em modelos animais de DII; muito limitado em humanos)

This content is informational. Consult a healthcare professional before using any peptide.